Identify potential responders to your IO therapy

Live tumor profiling for real-time immunotherapy prediction 

Clinical trials are an expensive and complex aspect of drug development. The ability to anticipate therapeutic response to immunotherapy prior to enrolling in a clinical trial is transformative.


At Elephas, we developed a novel platform that evaluates the likelihood of response to your treatment. For five years, Elephas focused on solving the scientific challenges that stood in the way of leveraging live tumor tissue to test response. Today, our platform: 

  • Uses a live core needle biopsy
  • Cuts live tumor fragments using a proprietary cutting device
  • Protects and maintains the tumor microenvironment via a novel hydrogel
  • Solves for tumor heterogeneity leveraging a sequential treatment method
  • Assesses response to ICI treatment via cytokine response
  • Provides a detailed report on cytokine activation

Importantly, the platform is compatible with established functional assays as well as non-destructive spatial imaging, enabling researchers to characterize clinical response to ICI longitudinally.

What if you could evaluate the likelihood of response for your immuno-oncology agent prior to participant enrollment?

Elephas-LP-percentage-graphic-12Aug25

Go beyond the limitations of current predictive biomarkers with the Elephas Live™ Platform.

Preserve the tumor microenvironment

Elephas Live™ Edge is a customized automated cutting tool that precisely cuts the biopsy into live tumor fragments.  Elephas Live™ Protect is a proprietary hydrogel that maintains tissue architecture and cellular viability.

Analyze response to therapy 

Elephas Live™ Method profiles cytokines from the live tumor fragments at multiple time points over 72 hours. The live tumor fragments are treated sequentially with a negative control followed by an immune checkpoint inhibitor in the same well. This approach mitigates the challenges of tumor heterogeneity and tissue scarcity inherent to core needle biopsies.

See our poster from AACR 2025 for more detail.

Inform participant selection 

Elephas Live™ Reveal aggregates, visualizes, and returns data via a secure, cloud-based web portal. It features robust data security and role-based permissions to safeguard sensitive information.

Following analysis, treated samples can be preserved as FFPE blocks for downstream imaging and further analysis.

Ready to get into the details?

If you're interested in learning about how the Elephas Live™ Platform could accelerate your IO pipeline, fill out the form below and we'll be in touch.

Pooja Advani
Pooja Advani,
MBBD, MD

Medical Oncologist
Breast Cancer
Mayo Clinic
David Braun
David Braun,
MD, PhD

Medical Oncologist
Kidney Cancer
Yale School of Medicine
Christian Capitini
Christian Capitini, MD
Director
UW Health | Carbone Cancer Center
Kevin Eliceiri
Kevin Eliceiri, PhD
Professor of Microscopy, Medical Imaging & AI
The University of Wisconsin-Madison
Janis_Marie_Taube
Janis Marie Taube,
MD, MSc

Pathologist
Melanoma
Johns Hopkins Medicine