Pharma Services

A functional precision medicine platform to assess human immunotherapy responses and drive IO development

Clinical trials are an expensive and complex aspect of drug development. Optimizing clinical development is critical for launching approved therapies that patients need.

Elephas has developed a functional ex vivo platform that measures cytokine response in live tumor biopsies following treatment with a therapeutic agent. These insights will help you:

Prioritize therapeutic candidates for clinical development
Identify patient profiles to inform trial strategies
Identify combinations and comparisons
Identify potential biomarkers
Explore opportunities for future companion diagnostics

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Ex vivo cytokine profiling enables precision medicine

The ability to predict response prior to therapy initiation is transformative. Go beyond the limitations of current predictive biomarkers with the Elephas Live™ Platform.

The platform:

Uses a live core needle biopsy
Relies on proprietary technology to maintain TME and tumor heterogeneity
Detects T-cell response to ICI treatment
Uses sequential treatment to replicate combination treatment

Preserve the tumor microenvironment

Elephas Live™ Edge is a customized automated cutting tool that precisely cuts the biopsy into live tumor fragments. Get into the details with the Edge white paper.

Elephas Live™ Protect is a proprietary hydrogel that maintains tissue architecture and cellular viability. Review the Protect white paper for supporting data.

Analyze response to therapy

Elephas Live™ Method profiles cytokines from the live tumor fragments at multiple time points over 72 hours. The live tumor fragments are treated sequentially with a negative control followed by an immune checkpoint inhibitor in the same well. This approach mitigates the challenges of tumor heterogeneity and tissue scarcity inherent to core needle biopsies. The Method white paper offers a detailed overview of our approach.

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Optimize clinical development

You will receive a custom data report based on your project requirements that aggregates and summarizes key findings. At the end of the project, Elephas will meet with your team to formally present and discuss outcomes. Elephas will also provide raw data to facilitate in-house analysis.

Following analysis, treated samples can be preserved as FFPE blocks for downstream imaging and further analysis.